2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W142432S
    Perfluoroundecanoic acid-13C7
    Perfluoroundecanoic acid-13C7 is the 13C-labeled Perfluoroundecanoic acid (HY-W142432). Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation.
    Perfluoroundecanoic acid-13C7
  • HY-W144308R
    Tetrachlorohydroquinone (Standard) 87-87-6
    Tetrachlorohydroquinone (Standard) is the analytical standard of Tetrachlorohydroquinone (HY-W144308). This product is intended for research and analytical applications. Tetrachlorohydroquinone (TCHQ) is a metabolite of Pentachlorophenol. Tetrachlorohydroquinone induces reactive oxidant stress (ROS), inhibits apoptosis and induces necrosis in primary mouse splenocytes. Tetrachlorohydroquinone increases DNA lesions and induces oxidative stress in rodents.
    Tetrachlorohydroquinone (Standard)
  • HY-W145584S
    D-Iditol-13C 98%
    D-Iditol-13C is the 13C labeled D-Iditol. D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity.
    D-Iditol-13C
  • HY-W385577A
    (S)-2-Benzylpyrrolidine hydrochloride 98%
    (S)-2-Benzylpyrrolidine hydrochloride (Compound s1) serves as a METH hapten scaffold. (S)-2-Benzylpyrrolidine hydrochloride attenuates Methamphetamine-induced hyperlocomotion, hyperthermia and respiratory depression. (S)-2-Benzylpyrrolidine hydrochloride alleviates Fentanyl-induced respiratory depression.
    (S)-2-Benzylpyrrolidine hydrochloride
  • HY-W399297R
    Isodeoxycholic acid (Standard) 566-17-6
    Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) Standard is the analytical standard of Isodeoxycholic acid (HY-W399297). This product is intended for research and analytical applications. Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) is a 3β-hydroxylated secondary bile acid. Isodeoxycholic acid is produced by epimerization of deoxycholic acid by intestinal bacteria. Isodeoxycholic acid is detectable in feces, mainly existing as saponifiable conjugates with long-chain fatty acids. Isodeoxycholic acid participates in the regulation of intestinal physiology.
    Isodeoxycholic acid (Standard)
  • HY-W403933R
    12-Ketochenodeoxycholic acid (Standard) 2458-08-4
    12-Ketochenodeoxycholic acid (Standard) is an analytical standard of 12-Ketochenodeoxycholic acid (HY-W403933). This product is intended for research and analytical applications. 12-Ketochenodeoxycholic acid is an anomalous bile acid and Chenodeoxycholic acid (HY-76847) precursor. 12-Ketochenodeoxycholic acid can be used for the research of hepatobiliary diseases.
    12-Ketochenodeoxycholic acid (Standard)
  • HY-W540836R
    Tritriacontane (Standard) 630-05-7
    Tritriacontane (Standard) is the analytical standard of Tritriacontane. This product is intended for research and analytical applications. Tritriacontane is an ester product.
    Tritriacontane (Standard)
  • HY-W590534S
    1-Palmitoyl-sn-glycero-3-phosphocholine-d3 2692624-19-2 98%
    1-Palmitoyl-sn-glycero-3-phosphocholine-d3 is a deuterated phosphocholine.
    1-Palmitoyl-sn-glycero-3-phosphocholine-d3
  • HY-W706672R
    Propane-1,2,3-triyl tritricosanoate (Standard) 86850-72-8
    Propane-1,2,3-triyl tritricosanoate (Standard) is the analytical standard of Propane-1,2,3-triyl tritricosanoate. This product is intended for research and analytical applications. 1,2,3-Tritricosanoyl glycerol is a triacylglycerol that contains tricosanoic acid (HY-W009081) at the sn-1, sn-2, and sn-3 positions. It has been used as an internal standard for the quantification of fatty acids in the triglyceride component of human aortic endothelial cells (HAECs) grown in media supplemented with stearic and/or oleic acid.
    Propane-1,2,3-triyl tritricosanoate (Standard)
  • HY-W718035S
    1-Chloro-3-(octanoyloxy)propan-2-yl decanoate-13C3 2692623-38-2 98%
    1-Chloro-3-(octanoyloxy)propan-2-yl decanoate-13C3 is a glycerolipid.
    1-Chloro-3-(octanoyloxy)propan-2-yl decanoate-13C3
  • HY-W718041S
    1-Lauroyl-2-decanoyl-3-chloropropanediol-13C3 2692623-37-1 98%
    1-Lauroyl-2-decanoyl-3-chloropropanediol-13C3 is an isotope labeled 3-monochloropropanediol (3-MCPD) glycidyl ester.
    1-Lauroyl-2-decanoyl-3-chloropropanediol-13C3
  • HY-W726667A
    (R)-(-)-Citramalic acid lithium 2319882-36-3 98%
    (R)-(-)-Citramalic acid ((R)-Citramalate) lithium, a lithium salt of Citramalic acid, is the R enantiomer of Citramalic acid lithium. (R)-(-)-Citramalic acid lithium is involved in the metabolism of glutamate through the methylaspartate pathway. (R)-(-)-Citramalic acid lithium is promising for research of neurological disorders.
    (R)-(-)-Citramalic acid lithium
  • HY-W741755A
    5-Hydroxy saxagliptin hydrochloride
    5-Hydroxy saxagliptin hydrochloride is an active metabolite of Saxagliptin (HY-10285) and a potent and selective DPP-4 inhibitor. 5-Hydroxy saxagliptin hydrochloride has Ki values of 2.6 nM and 2.9 nM for humans and cynomolgus monkeys, respectively. 5-Hydroxy saxagliptin hydrochloride can be used in the research of type 2 diabetes mellitus.
    5-Hydroxy saxagliptin hydrochloride
  • HY-W775262S
    Δ9-Tetrahydrocannabinolic acid-d3 1548417-60-2 98%
    Δ9-Tetrahydrocannabinolic acid-d3 is the deuterium labeled Δ9-Tetrahydrocannabinolic acid. Δ9-Tetrahydrocannabinolic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
    Δ9-Tetrahydrocannabinolic acid-d3
  • HY-W777870S
    1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5 2489621-95-4 98%
    1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5 is a deuterated 3-monochloropropanediol (3-MCPD) glycidyl ester.
    1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5
  • HY-W777873S
    (9Z,12Z,15E)-1-Palmitoyl-2-linolenoyl-3-chloropropanediol-d5 2734920-44-4 98%
    (9Z,12Z,15E)-1-Palmitoyl-2-linolenoyl-3-chloropropanediol-d5 is a deuterated 3-monochloropropanediol (3-MCPD) glycidyl ester.
    (9Z,12Z,15E)-1-Palmitoyl-2-linolenoyl-3-chloropropanediol-d5
  • HY-W906543A
    3-(2',5'-Disulfophenylimino)-3H-phenothiazine sodium 1419158-69-2
    3-(2',5'-Disulfophenylimino)-3H-phenothiazine sodium (Compound M2) is a lectron-transfer mediator. 3-(2',5'-Disulfophenylimino)-3H-phenothiazine sodium offers good enzyme reactivity and interference-free electrocatalysis of NADH. 3-(2',5'-Disulfophenylimino)-3H-phenothiazine (sodium) can be used for the research of type 2 diabetes.
    3-(2',5'-Disulfophenylimino)-3H-phenothiazine sodium
  • HY-WAA0142R
    L-Prolylglycine (Standard) 2578-57-6
    6-Ketoestradiol (Standard) is the analytical standard of 6-Ketoestradiol. This product is intended for research and analytical applications. 6-Ketoestradiol can be used to synthesize re-containing 7α-substituted estradiol complexes.
    L-Prolylglycine (Standard)
  • HY-113143AS1
    Galactose 1-phosphate-13C-1 potassium 478518-80-8 99.16%
    Galactose 1-phosphate-13C-1 (potassium) is the 13C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug.
    Galactose 1-phosphate-13C-1 potassium
  • HY-113308AS2
    Taurolithocholic acid-d4-1 sodium 98%
    Taurolithocholic acid-d4-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
    Taurolithocholic acid-d4-1 sodium
Cat. No. Product Name / Synonyms Application Reactivity